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There is an increased risk of uterine and endometrial cancer, it is essential to have regular checkups and to report any unusual vaginal bleeding to your doctor immediately. Because Premarin can increase the risk of heart attack, or stroke. What is the most important information I should know about conjugated estrogens? Estrogens may increase your risk of breast cancer. Menopause such as hot flashes, and vaginal dryness, burning, and irritation. What is the most important information I should know about conjugated estrogens? This medication may actually increase your risk of stroke or blood clots.