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With or without food. Paxil is well established in treating depression after nearly ten years and over ten million patient treatments. Zoloft, Paxil, Luvox and Prozac are currently used by more than five million Americans. As long as your doctor advises. Paxil works by helping to restore the balance of certain natural chemicals in the brain. Depression can be triggered or worsened by life's difficulties. Paxil is well established in treating depression after nearly ten years and over ten million patient treatments. Even per day, causing significant distress.