Fluconazole is used for the treatment of serious fungal infections, especially of the central nervous system. Diflucan comes with a patient information leaflet. Diflucan comes with a patient information leaflet. In common with all azole antifungal agents, Fluconazole may cause hepatotoxicity. Your doctor if you are pregnant or could become pregnant during treatment. Fluconazole is used to treat vaginal yeast infections.