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Depression, the most severe cognitive and behavioral malfunctions are expressed in what is called a major depressive disorder, which is also called clinical depression. You have any of the conditions listed above. Paxil should be taken once a day, either in the morning or evening, with or without food. It may take one month or more for you to start feeling better. Paxil is well established in treating depression after nearly ten years and over ten million patient treatments. With depression, the most severe cognitive and behavioral malfunctions are expressed in what is called a major depressive disorder, as stated by others. This drug must be taken regularly for a few weeks before its full effect is felt. If your doctor has prescribed Paxil for you, you are now taking an FDA-approved medication proven safe and effective for long-term use and is well tolerated.