Fluconazole works best when the amount of medicine in your body is kept at a constant level. Fluconazole is a very widely used antifungal agent. Fluconazole is commonly used for prophylaxis in transplant patients. If you feel well. Do not stop taking Diflucan without talking to your doctor if you have yeast infection, Diflucan is an oral antifungal agent that can be administered orally or parenterally.