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Fluconazole is commonly used for prophylaxis in transplant patients. Avoid alcohol or use it in moderation while taking Diflucan. Fluconazole is a very widely used antifungal agent. If you are allergic to it or to other antifungal drugs. In moderation while taking Diflucan. Ask your health care provider any questions you may have about how to use Fluconazole. Diflucan should be stored at room temperature away from moisture and sunlight. Diflucan comes as a tablet and liquid to take by mouth usually taken once a day.