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Searle celebrex: "Celecoxib should only be used in pregnant women when the benefits outweigh the potential risk to the fetus. Fluconazole increases the concentration of Celecoxib in the liver. This drug may rarely cause serious liver disease. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Before taking Celecoxib, tell your doctor or pharmacist if you are already taking Celebrex, it is important to keep taking it as instructed by your doctor."