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If your symptoms do not improve within a few days or if they become worse, check with your doctor. Zovirax may cause you to become sunburned more easily. Sometimes acyclovir is given to help prevent the infection from coming back. Treatment for cold sores. Follow dosing directions. Common side effects with Zovirax include loss of appetite and headache. Treatment with Acyclovir topical should be started as soon as possible after your symptoms begin. Your cold sore has not healed after five days of treatment, it may be continued for up to ten months. Acyclovir inhibits the replication of viral DNA needed to reproduce itself.
