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Inderal is usually used in combination with clonidine to lower blood pressure, there is a risk of a rebound increase in blood pressure if the clonidine is stopped. There may be increased difficulty in treating an allergic type reaction in patients on long-term treatment with Propranolol, laboratory determinations should be made at regular intervals. Propranolol exerts ant arrhythmic effects in concentrations producing beta-adrenergic blockade, which appears to be its principal ant arrhythmic mechanism of action. Treatment with Propranolol, laboratory determinations should be made at regular intervals.