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Prednisone is used in much higher doses than the levels of corticosteroids produced naturally by the body. It works by modifying the body's immune response to various conditions and decreasing inflammation. Prednisone to Prednisolone is impaired. You could have unpleasant withdrawal symptoms. Deltasone is used in so many conditions, only the most common or established uses are mentioned here. Corticosteroids, including prednisone, are commonly used to suppress the immune system and prevent the body from rejecting transplanted organs. Prednisone has very little mineral corticoid activity, so it is not used in the management of inflammatory conditions or diseases in which the immune system. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases.